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KMID : 0379520030190030241
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한국독성학회지
2003 Volume.19 No. 3 p.241 ~ p.245
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Acute Oral Toxicity of Paecilomyces sinclairii in Beagle Dogs
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Ahn Mi-Young
Kang Se-Chan
Jung Na-Jin
Koo Hyun-Jung
Kwack Seung-Jun
Yoo Eun-Jung
Jung Jin-A
Ko JIn-Kyung
Ryu Kang-Sun
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Abstract
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The acute toxicity of Paecilomyces sinclairii was tested in beagle dogs. We daily examined clinical signs, body weights, and hematological/biochemical examinations for 14 days after administration of Paecilomyces sinclairii with different dose levels (0, 0.4, 2 and 10 g/kg). There were no clinical signs and no significant changes in hematological and biochemical analysis. These results showed that Paecilomyces sinclairii did not induce any remarkable acute toxic response and the LD_{50} was greater than 10 g/kg in beagle dogs.
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KEYWORD
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Acute toxicity, Paecilomyces sinclairii, Beagle dogs.
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